Corona virus Vaccine
Today we will talk on the phase one trial in just over a thousand
people of this vaccine designed by Oxford University and now uh partnered with
AstraZeneca and the results are good we're seeing a good safety
profile across a large number of people and very importantly we're seeing
strong
Immune responses what does it mean for a potential timeline what
are the next steps if the immune responses are strong that suggests that the
vaccine is
more likely to work it doesn't prove that it will but we try and extrapolate
from preclinical data from all the clues we can work out from what we're
Seeing in the immunological detail and frankly we're encouraged in
terms of timeline it doesn't really change that we said that we were aiming for
Roundabout late third quarter early fourth quarter of this year to
get a first read on efficacy and that's still the goal but we do need enough
cases in our
Trials to be able to determine whether the vaccine is preventing
cases in the vaccines so that's still maybe October time something like that is
it also
difficult in the testing Adrian to figure out okay we know that
the fatality rate for younger people is statistically not zero but it's extremely
low I think the
cdc here in the united states of the 121 000 or so pure covid fatalities 844
have been under the age of 34. so 0.6 uh statistically obviously
every one of
those the life that we care about i'm not minimizing any of those
what I’m saying is are you able to find enough at-risk members of the
population who
are willing to undergo these vaccine trials we are not exposing
people in the current trial or in any planned trial to more covert than they
would get by
natural exposure there is this idea of deliberately infecting
people known as a challenge trial which is gaining increasing interest from
funders and from agencies around the world.
Vaccine on trials and its tests
I emphasize that has not started yet whether it would be safe I
think it probably would be is being discussed and of course how safe it is
depends on
How you do it how low a dose of challenge virus might be needed and whether you have some treatments available and in the coming months that's going to be discussed extensively and it may be a fast way to getting data on
whether the vaccine gives an effect gives protection in young
people as you say and very young people would be likely the subjects because
they're at a
lower risk of severe disease but that's not what what's happening
today we're reporting on a large vaccine trial in 18 to 55 year olds in the uk
showing that
the vaccine looks pretty safe and is very immunogenic stimulating both arms of the immune system and is it t cells and antibodies absolutely yes so this vaccine technology is particularly designed to induce t cells some vaccines
Really only induce antibodies ours induces antibodies at good
levels but also t cells measured in various t cell assays and that's becoming
of increasing
Interest because we observe people who recover from covet disease
and have very low antibody levels but some detectable t cells so it looks to
many of us
As if in natural infection t cells are contributing to protection
and therefore we'd like to uh mimic that by vaccination and that's exactly what
we're seeing
With this particular vaccine so what are the next steps the next
steps are to ramp up the numbers in our phase 3 trials we are using both a
single dose and
Two doses of the vaccine that looks as if both give useful immune responses even though after two doses we see stronger immune responses and to keep
Following these individuals and to start trials elsewhere including very importantly in in the us hopefully in the next few weeks and give us a reason
to be optimistic you know assuming you guys and your great team
are doing all this work and it continues at this pace you know what would be
sort of a
Realistic I don't want you to get ahead of yourself Adrian I know
we have a long way to go what would be a realistic estimate of you know
reasonable
Distribution of a working vaccine we've always said that we're
aiming to get this vaccine being administered being used by the end of this
year and
Because of that unusually we've gone to scale at manufacturing
with AstraZeneca with many partners very early on and AstraZeneca have now
Signed contracts for producing 2 billion doses of this vaccine over the next 12 months we won't have 2 billion doses by the end of the year but hopefully
We’ll have many millions and we'll be able to provide that for
at-risk individuals by the end of the year that's still the target you
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